Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain
- Author:
Omar M.E. ABDEL-SALAM
1
;
Amany A SLEEM
2
;
Eman R YOUNESS
3
;
Nadia A MOHAMMED
3
;
Enayat A OMARA
4
;
Omar M.E. ABDEL-SALAM
1
Author Information
- Publication Type:Journal Article
- Keywords: B cell/lymphoma-2; Brain oxidative stress; Misoprostol; Paraoxonase; Rotenone
- From: Asian Pacific Journal of Tropical Medicine 2018;11(1):40-47
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods: Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of 10, 100 or 1 000
