An updated systematic review of Zika virus-linked complications

Braira Wahid; Amjad Ali; Muhammad Waqar; Muhammad Idrees; Braira Wahid; Muhammad Waqar; Muhammad Idrees; Muhammad Idrees; Amjad Ali

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An updated systematic review of Zika virus-linked complications

Author: Braira WAHID ¹ ; Amjad ALI ¹ ; Muhammad WAQAR ¹ ; Muhammad IDREES ¹ ; Braira WAHID ² ; Muhammad WAQAR ² ; Muhammad IDREES ² ; Muhammad IDREES ³ ; Amjad ALI ¹
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1. Centre for Applied Molecular Biology, University of the Punjab
2. Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society
3. Hazara University
Publication Type:Journal Article
Keywords: Acute myelitis; Guillain-Barre syndrome; Hydrancephaly/hydrops fetalis; Meningoencephalitis; Microcephaly; Myasthenia gravis; Zika virus
From: Asian Pacific Journal of Tropical Medicine 2018;11(1):1-8
CountryChina
Language:Chinese
Abstract: Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library. Only those research articles, case studies, case-control studies, case-cohort studies, cross-sectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis, meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.