Traditional medicines and their in-vitro proof against Staphylococcus aureus in Pakistan

Muhammad Adnan; Roqaia Bibi; Sakina Mussarat; Bibi Fatima; Akash Tariq; Akash Tariq; Nawab Ali; Hazir Rahman; Zabta Shinwari

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Traditional medicines and their in-vitro proof against Staphylococcus aureus in Pakistan

Author: Muhammad ADNAN ¹ ; Roqaia BIBI ¹ ; Sakina MUSSARAT ¹ ; Bibi FATIMA ¹ ; Akash TARIQ ² ; Akash TARIQ ³ ; Nawab ALI ⁴ ; Hazir RAHMAN ⁵ ; Zabta SHINWARI ⁶
Author Information

1. Department of Botany, Kohat University of Science and Technology
2. Key Lab. of Mt. Ecol. Restoration and Biorsrc. Utiliz. and Ecol. Restoration Biodiv. Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences
3. University of Chinese Academy of Sciences
4. Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology
5. Department of Microbiology, Abdul Wali Khan University
6. Department of Biotechnology and Bioinformatics, Quaid-i-Azam University
Publication Type:Journal Article
Keywords: Gram positive bacteria; Herbal medicines; In-vitro; Phytochemicals; Plant extracts
From: Asian Pacific Journal of Tropical Medicine 2018;11(6):355-368
CountryChina
Language:Chinese
Abstract: Objective: To gather the fragmented literature on ethnobotany, phytochemistry and in-vitro activities of medicinal plants of Pakistan being used against common infections caused by Staphylococcus aureus (S. aureus). Methods: A large number of published and unpublished research studies related to the ethnomedicinal, phytochemical and anti-S. aureus activity of medicinal flora of Pakistan published from 1990-2018 were reviewed using online bibliographic databases such as PubMed, Web of Science, Science Direct, ResearchGate and libraries. Results: S. aureus can cause many human ailments including endocarditis, staphylococcal scalded skin syndrome, septic arthritis, respiratory problems with an estimated infection rate of 25%-35% across the globe. This review comprised of 86 medicinal plants. Data showed that people mostly used leaves (50%) for the preparation of traditional medicines. Correlation analysis on the reviewed data revealed that methanolic extract concentrations of medicinal plants was highly significantly positive correlated (r=0.8; P<0.01) with the S. aureus zone of inhibitions. S. aureus reportedly showed complete resistant to the commonly used antibiotic erythromycin. Isolated compounds like altheahexacosanyl lactone, cinnamaldehyde, niloticane, gobicusin A, asparacosin A, muzanzagenin, isoagatharesinol, friedelin, inophynone and eugenol were active against S. aureus. This study provided in-vitro proof for the flora of Pakistan used against different infections caused by S. aureus. Conclusions: Antibacterial agents from natural sources could be more effective against bacterial pathogens and will be helpful in minimizing the adverse effects of synthetic drugs, and hence provides a base for the pharmaceutical industries. http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=6;spage=355;epage=368;aulast=Adnan;type=2.