Research progress on the mechanisms of the latency and recurrence of herpes simplex virus type Ⅰ in trigeminal ganglion
10.3980/j.issn.1672-5123.2023.5.14
- VernacularTitle:单纯疱疹病毒Ⅰ型在三叉神经节潜伏复发机制的研究进展
- Author:
Ya-Hui DONG
1
;
Ge ZHAO
1
;
Qing-Jun ZHOU
1
Author Information
1. Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
herpes simplex virus;
latency;
molecular mechanisms;
trigeminal ganglion
- From:
International Eye Science
2023;23(5):787-790
- CountryChina
- Language:Chinese
-
Abstract:
Herpes simplex keratitis(HSK), caused by the infection of herpes simplex virus type Ⅰ(HSV-1)in cornea, is a global blinding corneal disease. After the primary infection in ocular surface, HSV-1 is transported into trigeminal ganglion and establishes the life-lasting latency, and it results in recurrent keratopathy. In the process of studying the latent mechanism of HSV, it has been gradually recognized that both the virus itself and the host response regulate the latent process of HSV. In recent years, a large number of research results have been obtained on the molecular mechanisms of invasion, immunity, latency and recurrence of neurotropic viruses, which provide new ideas for the prevention and treatment of HSK. In the present review, the recent progress of HSV latency mechanism in trigeminal ganglion after the primary infection in corneal surface was introduced, and the unsolved basic and clinical problems in HSK were discussed.
