Role of interleukin-6 in ocular inflammatory diseases
10.3980/j.issn.1672-5123.2023.5.11
- VernacularTitle:IL-6在眼部炎性疾病中的作用
- Author:
Yuan-Yuan TU
1
;
Man-Hui ZHU
1
Author Information
1. Lixiang Eye Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
interleukin-6(IL-6);
inflammation;
keratitis;
uveitis;
retinopathy;
thyroid-associated ophthalmopathy
- From:
International Eye Science
2023;23(5):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-6(IL-6)is a pleiotropic cytokine produced by monocytes, macrophages, T lymphocytes and other cell types. It is significantly up-regulated in the process of infection and inflammation, and is the core cytokine of the host's defense against environmental stresses(such as injury and infection). Abnormal and persistent IL-6 production is closely associated with the development of various autoimmune and inflammatory diseases. A growing number of studies have shown that IL-6 plays a critical role in ocular inflammation and angiogenesis in the conjunctiva, cornea, uvea and retina. Blockade of IL-6 ameliorates chronic and refractory intraocular inflammation. This article aims to review the role as well as the mechanism of IL-6 in ocular inflammatory diseases, attempting to have a deep and systematic understanding of the role of IL-6 in ocular inflammatory diseases.
