Effects of Morroniside on Apoptosis in Rats with Focal Cerebral Ischemia/Reperfusion Injury
- VernacularTitle:莫诺苷对大鼠脑缺血再灌注神经凋亡的影响
- Author:
Wen WANG
;
Dongming XU
;
Jie XIANG
;
Lei LI
;
Peichang WANG
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
morroniside, cerebral ischemia/reperfusion, glutathione, apoptosis, neuroprotective
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(12):1101-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of morroniside on glutathione (GSH) and Caspase-3 in rats with focal cerebral ischemia/reperfusion. Methods The animal model was induced by middle cerebral artery occlusion with suture embolus with 30 min for cerebral ischemia and 7 d for reperfusion. The content of GSH was detected with spectrophotometry and Caspase-3 expression was observed by Western blot.Results Compared with model group, the GSH increased and Caspase-3 expression reduced significantly at 270 mg/kg of morroniside.Conclusion Morroniside may have neuroprotective effect by increasing GSH in rats cortex and reduce the apoptosis in focal cerebral ischemia/reperfusion injury.
