Hypoglycemic Effect and Mechanism of Chinese Medicine Saponins： A Review
10.13422/j.cnki.syfjx.20222102
- VernacularTitle:中药皂苷类成分的降糖作用及机制研究进展
- Author:
Chuan PENG
1
;
Xuefang HU
1
;
Zhengtao CHEN
1
;
Chenyu DOU
2
;
Peng YANG
2
;
Jingxin BI
3
;
Lei DING
3
;
Lili WU
4
;
Lingling QIN
5
;
Tonghua LIU
4
Author Information
1. School of Clinical Medicine，Chengdu University of Traditional Chinese Medicine，Chengdu 610036，China
2. The First School of Clinical Medicine，Shaanxi University of Chinese Medicine，Xi'an 711301，China
3. Second Clinical College of Beijing University of Chinese Medicine，Beijing 100078，China
4. Institute of Chinese Medicine Health Preservation，Beijing University of Chinese Medicine，Beijing 100029，China
5. Beijing University of Chinese Medicine，Beijing 100029，China
- Publication Type:Journal Article
- Keywords:
Chinese medicine saponins;
type 2 diabetes mellitus;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(11):266-275
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus （T2DM） is a chronic metabolic disease characterized by insulin resistance， hyperinsulinemia， and disturbance of glucose and lipid metabolism， with elevated blood glucose as the main clinical manifestation. Due to its complex etiology and pathogenesis， there is no effective treatment， which critically threatens human health and places a heavy burden on society and families. Saponins are a class of glycosides with complex structures that have the advantage of a wide range of sources， elevated safety， and low adverse effects. As an essential active ingredient in Chinese medicine， Chinese medicine saponins have a variety of biological activities such as hypoglycemia， hypoglycaemia， anti-inflammation， antioxidation， anti-tumor， and immune modulation. In recent years， numerous studies have shown that Chinese medicine saponins are effective in preventing and treating T2DM. Although there have been numerous studies on the hypoglycemic effects and mechanisms of Chinese medicine saponins， there has been no systematic review of the mechanisms of Chinese medicine saponins in the treatment of T2DM. Therefore， to provide a theoretical basis for an in-depth study of the hypoglycemic effects of Chinese medicine saponins and a scientific basis for the development and clinical application of drugs， this paper systematically summarized the hypoglycemic mechanisms of Chinese medicine saponins， such as improving islet β-cell function， improving insulin resistance， inhibiting glycosidase activity， reducing the inflammatory response， anti-oxidative stress， and regulating intestinal flora， and analyzed the current research problems and development trends.
