Chinese Medicine Intervenes in Diabetic Kidney Disease Based on p38 MAPK Signaling Pathway：A Review
10.13422/j.cnki.syfjx.20230139
- VernacularTitle:中药基于p38 MAPK信号通路干预糖尿病肾病的研究进展
- Author:
Peng YANG
1
;
Tonghua LIU
2
;
Lili WU
2
;
Lingling QIN
2
;
Chengfei ZHANG
2
;
Chuan PENG
3
;
Qiue ZHANG
2
Author Information
1. First Clinical School of Medicine， Shaanxi University of Chinese Medicine， Xianyang 712046， China
2. Key Laboratory of Chinese Medicine and Health Sciences， Ministry of Education， Beijing University of Chinese Medicine， Beijing 100029， China
3. Chengdu University of Traditional Chinese Medicine， Chengdu 610075， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
diabetic kidney disease;
p38 mitogen-activated protein kinase （p38 MAPK）;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(11):212-223
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD）， a major microvascular complication of diabetes mellitus， serves as the most common cause of end-stage renal disease worldwide. The progression of DKD is closely related to oxidative stress， inflammatory response， apoptosis， and fibrosis in renal tissues activated by high glucose. Numerous studies have shown that the transduction of the p38 mitogen-activated protein kinase （p38 MAPK） signaling pathway is involved in the pathological process of DKD in renal tissues， activating various pathological mechanisms， such as oxidation， inflammation， apoptosis， and fibrosis. Therefore， blocking the transduction of the p38 MAPK signaling pathway is beneficial to alleviating DKD. At present， the main treatment principles of western medicine are glucose lowering， lipid lowering， and blood pressure lowering， as well as medications with new drugs renal sodium-glucose co-transporter 2 （SGLT2）， mineralocorticoid receptor， and endothelin receptor， but the progression of DKD still cannot be stopped. The treatment of DKD by traditional Chinese medicine （TCM） has the advantages of simplicity， low cost， and convenience， and the symptoms and root causes can be both treated. In recent years， the basic research on Chinese medicine intervention in DKD has greatly advanced， and p38 MAPK is the key factor of Chinese medicine intervention in DKD. The present study searched and reviewed the literature on the Chinese medicine intervention in the p38 MAPK signaling pathway in DKD treatment in the past decade. The results showed that p38 MAPK interacted with transforming growth factor-β1 （TGF-β1）， cysteinyl aspartate-specific protease-3 （Caspase-3）， nuclear factor-κB （NF-κB）， and other factors to activate fibrosis， inflammation， oxidative stress， and apoptosis. By acting on p38 MAPK and its upstream and downstream factors， Chinese medicine blocked the pathological processes of DKD and inhibited the pathological injury of DKD and the deterioration of renal function. This study is expected to provide new ideas and directions for the prevention and treatment of DKD with Chinese medicine.
