Clinical Observation of Modified Yinqiaosan Combined with Antibiotics in Treatment of Acute Tonsillitis in Children with Wind-heat Invading Lung Syndrome
10.13422/j.cnki.syfjx.20230125
- VernacularTitle:银翘散加味联合抗生素治疗儿童急性扁桃体炎风热犯肺证的临床观察
- Author:
Jinghua QIAO
1
;
Linlin YU
1
;
Xiaoping JING
1
;
Xiaoyan DONG
1
;
Mingda GU
2
Author Information
1. Children's Hospital of Shanghai， Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine， Shanghai 200062， China
2. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China
- Publication Type:Journal Article
- Keywords:
acute tonsillitis;
tonsillitis;
syndrome of wind-heat invading lung;
modified Yinqiaosan;
children
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(11):121-125
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical effect of modified Yinqiaosan combined with antibiotics in the treatment of acute tonsillitis in children with wind-heat invading lung syndrome. MethodA total of 96 children with acute tonsillitis of wind-heat invading the lung syndrome were randomized into control group and observation group. The control group was treated with routine antibiotics， and the observation group was treated with modified Yinqiaosan and antibiotics for 7 days. The scores of major symptoms （sore throat， erythmatous throat， dysphagia， erythmatous tonsils and suppuration） and minor symptoms （fever， cough， stool， and tongue） and the levels of inflammation- and immune-related indexes ［white blood cell （WBC）， C-reactive protein （CRP）， serum amyloid A （SAA）， interleukin-6 （IL-6）， and interferon-γ （IFN-γ）］ were compared between two groups. ResultThe data of 92 children were statistically analyzed： 45 in the observation group and 47 cases in the control group. The total clinical effective rate of the observation group was 95.56%， as compared with the 93.62% of the control group. After treatment， the scores of major symptoms in the observation group were lower than those in the control group （P<0.05）， and the scores of cough， defecation， and tongue in the observation group were lower than those in the control group （P<0.05）. The levels of inflammation- and immune-related indexes after treatment in the observation group were lower than those before treatment （P<0.05）. Except IFN-γ， the levels of the inflammation- and immune-related indexes in the control group were lower than those before treatment （P<0.05）. After treatment， the levels of SAA and IL-6 in the observation group were lower than those in the control group （P<0.05）. ConclusionModified Yinqiaosan combined with antibiotics can significantly reduce the expression of SAA and IL-6 in the treatment of children with acute tonsillitis， thereby alleviating inflammation and clinical symptoms and improving prognosis.
