Research progress on pharmacological characteristics，safety and drug combination of remimazolam
- VernacularTitle:瑞马唑仑的药理特点、安全性及联合用药研究进展
- Author:
Tao JIA
1
,
2
;
Hui LIU
1
;
Jinliang TENG
1
Author Information
1. Dept. of Anesthesiology，the First Affiliated Hospital of Hebei North University，Hebei Zhangjiakou 075000，China
2. Graduate School of Hebei North University，Hebei Zhangjiakou 075000，China
- Publication Type:Journal Article
- Keywords:
remimazolam;
pharmacological characteristics;
safety;
combined medication;
clinical anesthesia
- From:
China Pharmacy
2023;34(8):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Remimazolam （toluenesulfonate） is a new type of ultra short-acting water-soluble benzodiazepine sedative-hypnotic drug， which was launched in China on December 26， 2019， for sedation during routine gastroscopy and colonoscopy as well as induction and maintenance under general anesthesia， breaking a 30-year period in which no innovative sedation drugs were marketed in China. This article reviewed the pharmacological characteristics， safety and combined use of remimazolam. Remimazolam had the advantages of high clearance rate， short action time， rapid recovery， stable hemodynamics， and low respiratory inhibition. It is independent of liver and kidney metabolism， and can be quickly antagonized by flumazenil， with little impact on the cognitive function of patients. Remimazolam has shown good respiratory and circulatory stability in combination with intravenous anesthetics such as propofol and esketamine， and opioid analgesics such as sufentanil， remifentanil， and alfentanil， as well as advantages such as rapid awakening and recovery. However， its safety still needs to be further monitored and explored during clinical use.
