Efficacy and safety of ropivacaine combined with alfentanil for analgesia after knee arthroscopic surgery
- VernacularTitle:罗哌卡因联合阿芬太尼对膝关节镜手术术后镇痛的有效性和安全性
- Author:
Yapeng HE
1
;
Zong YE
1
;
Lei LI
2
;
Hui QIN
2
;
Hao WU
2
;
Jia CHEN
3
;
Xianlin ZHU
3
Author Information
1. Graduate College，Hubei University of Medicine，Hubei Shiyan 442000，China
2. Dept. of Joint Surgery，the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture，Hubei Enshi 445000，China
3. Dept. of Anesthesiology，the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture，Hubei Enshi 445000，China
- Publication Type:Journal Article
- Keywords:
knee arthroscopic surgery;
alfentanil;
ropivacaine;
analgesic effect;
safety
- From:
China Pharmacy
2023;34(8):974-977
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the efficacy and safety of intra-articular injection of ropivacaine combined with alfentanil for postoperative analgesia in patients who underwent knee arthroscopic surgery. METHODS A total of 60 patients who underwent knee arthroscopic surgery were collected from the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from March to September in 2022， and then divided into trial group and control group with random number table method， with 30 cases in each group. The control group received intra-articular injection of 0.25% ropivacaine 50 mg， and the trial group received intra-articular injection of 0.25% ropivacaine 50 mg+alfentanil 0.15 μg/kg.The first postoperative remedial analgesia time， the total amount of postoperative remedial drugs， numerical rating scale at rest （NRS-R） scores， numerical rating scale at movement （NRS-M） scores， heart rate， mean arterial blood pressure， and pulse oxygen saturation during exercise at different monitoring time points after surgery， the incidence of adverse drug reactions such as hypotension， respiratory depression， nausea， and vomiting after surgery were compared between 2 groups. RESULTS Compared with the control group， the first postoperative remedial analgesia time was significantly longer in the trial group， and the total amount of postoperative remedial drugs was significantly reduced （P＜0.001）. The trial group had lower NRS-R and NRS-M scores at each monitoring time point， with statistically significant differences （P＜0.001）， and there was an interactive effect between time and groups （P＜0.001）. The changes in heart rate， mean arterial blood pressure， and pulse oxygen saturation of patients in the trial group were relatively small， with no statistically significant differences （P＞0.05）， and there was no interactive effect between time and groups （P＞0.05）. There was no statistical significance in the incidence of adverse drug reactions between 2 groups， such as postoperative hypotension， respiratory depression， nausea， vomiting （P＞0.05）. CONCLUSIONS The intra- articular injection of ropivacaine combined with alfentanil shows good efficacy and safety for post-knee arthroscopic analgesia， and significantly prolongs the analgesic duration of ropivacaine.
