HbA1c and Myocardial lschemia detected via Myocardial Perfusion Scintigraphy in type 2 Diabetes Mellitus
- Author:
Henry G. Canizares
1
;
Allanbert G. Sampana
1
;
Michele D. Ogbac
1
Author Information
1. Division of Nuclear Medicine, Philippine Heart Center, East Avenue, Quezon City
- Publication Type:Other Types
- MeSH:
Myocardial Perfusion Imaging;
Coronary Artery Disease;
Diabetes Mellitus, Type 2;
Glycated Hemoglobin;
Diabetes Complications
- From:
The Philippine Journal of Nuclear Medicine
2018;13(2):45-53
- CountryPhilippines
- Language:English
-
Abstract:
Background/Objective:Coronary Artery Disease (CAD) is the leading cause of mortality among patients with type 2 diabetes mellitus. Several studies evaluated glycemic control and MPS resultswith good correlation. In the Philippines, data concerning this matter are few, hence this study.
Methodology:This is a cross-sectional study of selected Filipino patients with type 2 diabetes mellitus without previous cardiac events who underwent stress or pharmacologic stress MPS (TI-201 or Tc-99m sestamibi) over an 18-month period at the Philippine Heart Center. Electrocardiogram and 2D echocardiogram results were also noted. Patients were grouped into adequate glycemic control (HbA1c<7.0%) and inadequate glycemic control (HbA1c >7.0%). Binary logistic regression was computed to determine association of glycemic control to MPS defects.
Results:A total of 206 subjects (114 HBa1C <7.0%, 92 with HbA1c ? 7.0%), were included in the study; with male predominance. Mean HbA1c values showed direct correlation; the higher the HbA1c values, the more MPS defects. Inadequate glycemic control group had significanlty higher subjects with mild and moderate to severe degree of myocardial ischemia (p<0.001). the relative risk of having a significant CAD in the inadequate glycemic control group is 4.30 times more than their counterpart (p<0.001). Factoring the duration of inadequate glycemic control to > 10 years, relative risk increased to 7.63
Conclusion:The study shows that patients with type 2 diabetes mellitus with inadequate glycemic control have increased MPS defects and highter relative risk for having significant CAD. Diabetic patients with inadequate glycemic control for > 10 years have an even higher risk of having significant CAD.
- Full text:HbA1c.pdf
