Morroniside Inhibiting Lipid Peroxidation of Cortex in Rats with Focal Cerebral Ischemia/Reperfusion
- VernacularTitle:莫诺苷抑制大鼠脑缺血再灌注模型皮层脂质过氧化作用的研究
- Author:
Lei LI
;
Dongming XU
;
Wen WANG
;
Peichang WANG
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Morroniside, ischemia/reperfusion, malondialdehyde (MDA), lipid peroxidation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(11):1015-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of morroniside on lipid peroxidation of cortex in rats with focal cerebral ischemia/reperfusion. Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 min, and reperfusion for 72 h in rats. The content of malondialdehyde (MDA) was detected with spectrophotometry. Results Compared with sham group, the content of MDA increased obviously in model rat. Compared with model group, Morroniside（30 mg/kg，90 mg/kg，270 mg/kg）and vitamin E（35 mg/kg） decreased the content of MDA significantly (P<0.05). Conclusion Morroniside may protect the cortex from lipid peroxidation.
