Behavior Observation on Learning and Memory Ability of Brain Aging Mice Intervened by Exercise and Diet
- VernacularTitle:运动和饮食因素对脑老化小鼠学习记忆能力影响的行为学观察
- Author:
Zhongxin XIAO
;
Shaojun YUN
;
Xiaojuan HE
;
Wei JIANG
;
Kaiwen HE
;
Shougang WEI
- Publication Type:Journal Article
- Keywords:
high fat, encephalon aging, learning and memory, Morris water maze
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(10):932-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effects for exercise and diet on learning and memory ability in mice with encephalon aging induced by D-galactose(D-gal).Methods The model of mice with encephalon aging was made by D-gal.The learning and memory ability of mice was determined by Morris water maze.Results There was significant difference between high fat feed encephalon aging group and restrict food on normal feed encephalon aging group,normal feed and exercise encephalon aging group,high fat feed and exercise encephalon aging group,high fat feed normal group,normal feed and exercise group,normal feed group(all P<0.05).In spatial probe test,there was significant difference between restrict food on normal feed encephalon aging group and normal feed encephalon aging group(all P<0.05).Conclusion Exercise and restrict food can improve the learning and memory function in the mice;feed with high fat can promote encephalon aging.
