Relationship between Changes of Exercise Induced Insulin-like Growth Factor-1 in Hippocampus and Ability of Learning Memory(review)
- VernacularTitle:运动诱导海马内IGF-1的变化与学习记忆能力的关系
- Author:
Zhaohui MENG
;
Bo XU
;
Shichang LI
;
Tao HUANG
;
Haizhen YU
- Publication Type:Journal Article
- Keywords:
exercise, insulin-like growth factor-1, learning memory, hippocampus, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(10):912-914
- CountryChina
- Language:Chinese
-
Abstract:
Recent study demonstrated that insulin-like growth factor-1(IGF-1) could have benefits to improve the learning memory.Exercise can increase IGF-1 level in hippocampus.IGF-1 may mediate exercise inducing learning memory;one of the possible mechanism is that the IGF-1 and brain derived neurotrophic factor(BDNF) has a common regulatory capacity over calcium/calmodulin-dependent protein kinase Ⅱ(CAMKⅡ),mitogen-activated protein kinase Ⅱ(MAPKⅡ) and synapsin-1,and the convergence of multiple signaling pathways mediate synaptic plasticity and improve learning memory.
