Role of A-kinase anchor protein 12 in chronic liver diseases

VernacularTitle:激酶锚定蛋白12在慢性肝病中的作用
Author: Haijian DONG ^{1
,

2} ; Hui LI ¹ ; Yujing TAO ^{1
,

2} ; Jialing GUO ^{1
,

2} ; Yuru ZHONG ^{1
,

2} ; Zijian ZENG ^{1
,

2}
Author Information

1. Central Laboratory, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2. School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
Publication Type:Review
Keywords: A Kinase Anchor Proteins; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease; Liver Diseases, Alcoholic; Carcinoma, Hepatocellular
From: Journal of Clinical Hepatology 2023;39(3):718-722
CountryChina
Language:Chinese
Abstract: A-kinase anchor protein 12 (AKAP12) is a scaffold protein that improves the specificity and efficiency of spatio-temporal signals by assembling intracellular signal proteins into specific complexes. In recent years, the role of AKAP12 in chronic liver diseases has attracted more and more attention. This article introduces the physiological functions of AKAP12 and reviews the role of AKAP12 in chronic liver diseases, in order to lay a foundation for the use of AKAP12 small molecule as a new therapeutic target for chronic liver diseases.