Role of gasdermin D in the pathological progression of liver diseases
10.3969/j.issn.1001-5256.2023.03.035
- VernacularTitle:消皮素D在肝脏疾病病理进展中的作用
- Author:
Feiyan LI
1
,
2
;
Minggang WANG
2
;
Dewen MAO
3
;
Xiongbin GUI
3
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China
2. Department of Scientific Research, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
3. Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Review
- Keywords:
Liver Diseases;
Gasdermin D;
Pathologic Processes;
Cell Death
- From:
Journal of Clinical Hepatology
2023;39(3):707-712
- CountryChina
- Language:Chinese
-
Abstract:
As a novel star molecule, gasdermin D (GSDMD) plays an important role in the amplification of immune inflammatory response and the process of pyroptosis. After being cleaved and activated by caspase-1, the N-terminal of GSDMD is rapidly released, which anchors on the cell membrane and forms pores, thereby leading to pyroptosis, accompanied by the release of a large amount of the strong proinflammatory factors IL-1β and IL-18. Acute/chronic liver inflammatory response and cell death are the common pathological features of liver diseases such as viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune liver disease, liver failure, and hepatocellular carcinoma. This article summarizes the basic structural characteristics of GSDMD and elaborates on its important role in the pathological progression of various liver diseases. In addition, it is proposed that prevention and treatment strategies with GSDMD as a potential therapeutic target can provide new ideas for further studies on the clinical prevention and treatment of liver diseases.
