Role of stem cell-derived exosomes in treatment of liver diseases
10.3969/j.issn.1001-5256.2023.03.034
- VernacularTitle:干细胞衍生的外泌体在肝脏疾病治疗中的作用
- Author:
Zhuoran WANG
1
,
2
;
Bing ZHU
2
;
Limei YU
1
,
3
,
4
;
Shaoli YOU
2
Author Information
1. Guizhou Provincial Key Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China
2. Division of Liver Disease, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
3. Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine, Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563001, China
4. Zunyi Stem Cell and Regenerative Medicine Engineering Research Center, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China
- Publication Type:Review
- Keywords:
Liver Diseases;
Stem Cells;
Mesenchymal Stem Cells;
Exosomes
- From:
Journal of Clinical Hepatology
2023;39(3):699-706
- CountryChina
- Language:Chinese
-
Abstract:
The liver is easily affected by a variety of factors to induce liver damage, which can cause disorders in the synthesis, detoxification, metabolism, and biotransformation functions of the liver in severe cases, and at present, there is still a lack of efficient clinical treatment methods for end-stage liver diseases such as liver failure and decompensated liver cirrhosis. Recent studies have confirmed the clinical efficacy of stem cells, and treatment methods based on stem cell-derived exosomes have become a research hotspot. This article introduces the advantages of treatment based on stem cell-derived exosomes, the research advances in related mechanisms, and the current status of preclinical research. Current research findings suggest that treatment based on stem cell-derived exosomes has a good application prospect in the treatment of liver diseases, but it is still needed to conduct in-depth preclinical and clinical studies.
