Influence of the interaction between tumor microenvironment and liver cancer stem cells on the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2023.03.032
- VernacularTitle:肿瘤微环境与肝癌干细胞相互作用对肝细胞癌发生发展的影响
- Author:
Yanxin TIAN
1
;
Na LI
1
;
Lei GAO
1
;
Jia WU
1
;
Ying ZHU
1
Author Information
1. Department of Infectious Diseases, Liver Disease Center for Combined TCM and Western Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China
- Publication Type:Review
- Keywords:
Carcinoma, Hepatocellular;
Neoplastic Stem Cells;
Tumor Microenvironment
- From:
Journal of Clinical Hepatology
2023;39(3):684-692
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, liver cancer stem cells (LCSC) have been considered one of the main causes of treatment failure and recurrence of hepatocellular carcinoma (HCC). Many studies have shown that LCSC are a small fraction of cells with the abilities of self-renewal, differentiation, and tumorigenesis in HCC tumor, which can initiate the onset of HCC and affect its proliferation, invasion, metastasis, recurrence, and drug resistance. Therapies based on tumor microenvironment (TME) have been developed recently, and a number of studies have found that targeting the relevant elements of TME has a higher therapeutic value than targeting tumor cells themselves. TME is the microenvironment for the growth of LCSC and HCC cells, and it interacts with LCSC and has a synergistic effect, thereby playing a positive role in the development and progression of HCC. This article introduces how various cellular components and non-cellular components in TME interact with LCSC to regulate the development and progression of the HCC. In addition, this article also describes the molecular targets, therapies, and drugs associated with the main components of TME and LCSCs, in order to seek safer and more effective targeted therapies for HCC.
