Research advances in effective constituents of traditional Chinese medicine in intervention of autoimmune hepatitis-related signaling pathways
10.3969/j.issn.1001-5256.2023.03.029
- VernacularTitle:中药有效成分干预自身免疫性肝炎相关信号通路的研究进展
- Author:
Junyu HAO
1
;
Guangwei LIU
2
;
Lu XIE
1
;
Wenyan FAN
1
;
Hongxiu CHEN
1
Author Information
1. The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Review
- Keywords:
Hepatitis, Autoimmune;
Drugs, Chinese Herbal;
Signal Transduction
- From:
Journal of Clinical Hepatology
2023;39(3):663-670
- CountryChina
- Language:Chinese
-
Abstract:
As a chronic liver inflammation disease caused by the lack of immune tolerance, autoimmune hepatitis is regulated by various signaling pathways, such as the NF-κB/NLRP3 pathway, the SIRT1/Nrf2/HO-1 pathway, the Hippo-YAP/TAZ pathway, the JAK/STAT pathway, the PI3K/Akt pathway, and the TRAF6/JNK pathway. These pathways can play a role against autoimmune hepatitis by participating in the processes including the proliferation and apoptosis of cytokines, immune response, and oxidative stress. In view of the problems of suboptimal response, obvious adverse reactions, and high recurrence rate in the clinical application of hormones and immune preparations for the treatment of autoimmune hepatitis, this article summarizes the research articles on autoimmune hepatitis-related signaling pathways and the mechanism of effective constituents (glycosides, terpenoids, flavonoids, quinones, and phenols) in traditional Chinese medicine intervening against the disease process of autoimmune hepatitis through the above signaling pathways, in order to provide a theoretical basis for scientific and effective utilization of effective constituents in traditional Chinese medicine to develop anti-autoimmune hepatitis drugs.
