Value of different scoring models in predicting the survival of patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt
10.3969/j.issn.1001-5256.2023.03.016
- VernacularTitle:不同评分模型对肝硬化患者经颈静脉肝内门体分流术后生存的预测价值
- Author:
Yuyi LIU
1
;
Zhiyong MU
1
;
Lu HU
1
;
Jun WANG
1
;
Wei XIONG
2
;
Hong HU
3
;
Aimin LIU
4
;
Xuan AN
5
;
Yuqiang XU
6
;
Haodong YU
7
;
Jinneng WANG
8
;
Liangzhi WEN
1
;
Dongfeng CHEN
1
Author Information
1. Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Army Specialized Medical Center of Army Medical University & Daping Hospital, Chongqing 400042, China
2. Department of Gastroenterology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China
3. Department of Interventional Radiology, Nanchong Central Hospital, North Sichuan Medical College, Nanchong, Sichuan 637000, China
4. Department of Gastroenterology, Chongqing University Fuling Hospital, Chongqing 408000, China
5. Department of Hepatology, Chongqing University Three Gorges Hospital, Chongqing 404100, China
6. Department of Gastroenterology, The People's Hospital of Leshan, Leshan, Sichuan 614000, China
7. Department of Gastroenterology, Chongqing University Qianjiang Hospital, Chongqing 409000, China
8. Department of Gastroenterology, The Ninth People's Hospital of Chongqing, Chongqing 400042, China
- Publication Type:Original Article_Liver Fibrosis and Liver Cirrhosis
- Keywords:
Liver Cirrhosis;
Portal Hypertension;
Portasystemic Shunt, Transjugular Intrahepatic
- From:
Journal of Clinical Hepatology
2023;39(3):590-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the value of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD combined with serum sodium concentration (MELD-Na) score, CLIF Consortium Acute Decompensation (CLIF-C AD) score, and Freiburg index of post-transjugular intrahepatic portosystemic shunt (TIPS) survival (FIPS) score in predicting the survival of patients undergoing TIPS. Methods A retrospective analysis was performed for the clinical data of 447 patients with liver cirrhosis who underwent TIPS in several hospitals in southwest China, among whom there were 306 patients in the survival group and 62 in the death group. The scores of the above five models were calculated, and a survival analysis was performed based on these models. The independent samples t -test was used for comparison of normally distributed continuous data between groups, and the non-parametric Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the Pearson chi-square test was used for comparison of categorical data between groups; a multivariate Cox regression analysis was used for correction analysis of known influencing factors with statistical significance which were not included in the scoring models; the Kaplan-Meier method was used to evaluate the discriminatory ability of each model in identifying risks in the surgical population, and the log-rank test was used for analysis. The area under the receiver operating characteristic curve (AUC), C-index at different time points, and calibration curve were used to evaluate the predictive ability of each scoring model. Results Compared with the death group, the survival group had significantly lower age ( Z =2.884, P < 0.05), higher albumin ( t =3.577, P < 0.05), and Na + ( Z =-3.756, P < 0.05) and significantly lower proportion of patients with alcoholic cirrhosis ( χ 2 =22.674, P < 0.05), aspartate aminotransferase ( Z =2.141, P < 0.05), prothrombin time ( Z =2.486, P < 0.05), international normalized ratio ( Z =2.429, P < 0.05), total bilirubin ( Z =3.754, P < 0.05), severity of ascites ( χ 2 =14.186, P < 0.05), and scores of the five models (all P < 0.05). Survival analysis showed that all scoring models effectively stratified the prognostic risk of the patients undergoing TIPS. Comparison of the C-index of each scoring model at different time points showed that Child-Pugh score had the strongest ability in predicting postoperative survival, followed by MELD-Na score, MELD score, and CLIF-C AD score, and FIPS score had a relatively poor predictive ability; in addition, the prediction efficiency of each score gradually decreased over time. Child-Pugh score had the largest AUC of 0.832 in predicting 1-year survival rate after surgery, and MELD-Na score had the largest AUC of 0.726 in predicting 3-year survival rate after surgery, but FIPS score had a poor ability in predicting 1- and 3-year survival rates. Conclusion All five scoring models can predict the survival of patients with liver cirrhosis after TIPS and can provide effective stratification of prognostic risk for such patients. Child-Pugh score has a better ability in predicting short-term survival, while MELD-Na score has a better ability in predicting long-term survival, but FIPS score has a relatively poor predictive ability in predicting both short-term and long-term survival.
