Advances in in vitro induction of hepatocyte-like cells and the application of small-molecule compounds in inducing hepatocyte-like cells
10.3969/j.issn.1001-5256.2023.04.037
- VernacularTitle:肝样细胞的体外诱导及小分子化合物在肝样细胞诱导中的应用
- Author:
Wei TANG
1
;
Dongmei WANG
1
Author Information
1. Fujian Key Laboratory of Development and Neurobiology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China
- Publication Type:Review
- Keywords:
Hepatocyte-Like Cells;
Small Molecules;
Regenerative Medicine
- From:
Journal of Clinical Hepatology
2023;39(4):986-992
- CountryChina
- Language:Chinese
-
Abstract:
The induction of hepatocyte-like cells (HLCs) in vitro is one of the effective ways to obtain a large number of useful hepatocyte, and these HLCs can be used in disease modeling, drug design, and toxicological evaluation. At present, the induction of HLCs in vitro is mainly achieved by introducing exogenous transcription factors, cytokines or small-molecule compounds. Since small-molecule compounds have the advantages of structural diversity, controllable time and dose, and convenient and safe operation, scientists are devoted to screening out the small-molecule compounds to replace exogenous transcription factors and cytokines, and such compounds have a promising application prospect in the field of regenerative medicine. This article reviews the studies on the in vitro induction of HLCs from pluripotent stem cells and other adult stem cells and summarizes the application of small-molecule compounds in the in vitro induction of HLCs, in order to provide ideas and references for the in vitro induction of HLCs.
