Association between endoplasmic reticulum stress and ferroptosis in liver diseases

VernacularTitle:肝脏疾病中内质网应激与铁死亡的关系
Author: Lu YE ^{1
,

2
,

3} ; Xiuqin LI ^{1
,

2} ; Jianqing WANG ^{1
,

2}
Author Information

1. Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230012, China
2. Anhui Public Health Clinical Center, Hefei 230012, China
3. School of Pharmacy, Anhui Medical University, Hefei 230032, China
Publication Type:Review
Keywords: Liver Diseases; Endoplasmic Reticulum Stress; Ferroptosis
From: Journal of Clinical Hepatology 2023;39(4):980-985
CountryChina
Language:Chinese
Abstract: Research on the pathogenesis of liver diseases has attracted great attention. Endoplasmic reticulum stress (ERS) is a self-protective mechanism of cells, but sustained and severe ERS can induce apoptosis, autophagy, and ferroptosis, among which ferroptosis has been a research hotspot in recent years. Ferroptosis is mainly characterized by the accumulation of iron-dependent lipid peroxides and plays a key role in the development and progression of liver diseases, but there are currently few studies on the involvement of ERS in ferroptosis in liver diseases. This article summarizes the research advances in ERS-related signaling pathways, the mechanism of ferroptosis, and the involvement of ERS in liver diseases, so as to provide more ideas for research on the treatment of liver diseases.