Research advances in pathogenesis, risk factors, monitoring, and retreatment of drug-induced liver injury
10.3969/j.issn.1001-5256.2023.04.034
- VernacularTitle:药物性肝损伤发生机制、危险因素、监测以及再用药的研究进展
- Author:
Rujia LIU
1
;
Xiaojuan XIN
1
Author Information
1. Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Publication Type:Review
- Keywords:
Chemical and Drug Induced Liver Injury;
Risk Factors;
Retreatment
- From:
Journal of Clinical Hepatology
2023;39(4):968-973
- CountryChina
- Language:Chinese
-
Abstract:
With the approval and launch of a large number of new drugs, the incidence rate of drug-induced liver injury (DILI) is increasing year by year, which may affect the treatment of primary diseases. As an adverse drug reaction, DILI cannot be completely eliminated, and the clinical goal is to minimize its influence through prevention and control. This article reviews the research advances in the risk factors for DILI, the monitoring of DILI, and retreatment. Studies have shown that the risk of DILI can be increased by certain factors under some circumstances. Early identification of risk factors, rational monitoring, and focus on the timing and method for retreatment can reduce the development or progression of DILI and thus improve the prognosis of patients.
