The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2023.04.032
- VernacularTitle:p53信号通路调控铁死亡在肝细胞癌中的作用机制
- Author:
Zhen LI
1
;
Jiangkai LIU
2
Author Information
1. The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Review
- Keywords:
Ferroptosis;
Carcinoma, Hepatocellular;
Tumor Suppressor Protein p53
- From:
Journal of Clinical Hepatology
2023;39(4):956-960
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a new way of cell death, ferroptosis has huge potential in the treatment of HCC. This article introduces the mechanism of action of the tumor suppressor p53 in regulating ferroptosis and briefly describes its role in the development and progression of HCC. The tumor suppressor p53 can promote or inhibit ferroptosis by affecting solute carrier family 7 member 11, spermidine/spermine N1-acety-ltransferase 1, glutaminase 2, dipeptidyl peptidase 4, and cyclin-dependent kinase inhibitor 1A, which in turn affects the progression of HCC. The treatment of HCC by regulating the ferroptosis pathway has great application prospects.
