Application of immune checkpoint inhibitors in liver transplantation for patients with hepatocellular carcinoma
10.3969/j.issn.1001-5256.2023.04.030
- VernacularTitle:免疫检查点抑制剂在肝细胞癌肝移植中的应用
- Author:
Youcheng XIE
1
,
2
;
Shun CHEN
1
;
Chuyi LI
1
;
Ying ZHENG
1
;
Dong JIA
1
,
2
;
Jiucong ZHANG
1
;
Xiaohui YU
1
Author Information
1. Department of Gastroenterology, The 940 Hospital of Joint Service Support Force of the Chinese People's Liberation Army, Lanzhou 730050, China
2. The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China
- Publication Type:Review
- Keywords:
Carcinoma, Hepatocellular;
Liver Transplantation;
Immunosuppressive Agents
- From:
Journal of Clinical Hepatology
2023;39(4):941-947
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation, as one of the radical treatment strategies for hepatocellular carcinoma, has a good clinical effect in patients meeting the Milan criteria; however, the high recurrence rate and metastasis rate after surgery bring great challenges to the long-term survival of such patients. Therefore, how to improve long-term survival rate and reduce postoperative tumor metastasis has become a key problem that needs to be solved urgently. In recent years, immune checkpoint inhibitors (ICIs), with their good safety and objective reactivity, have provided a new opportunity for the treatment of patients with advanced liver cancer and have become potential candidates for improving the therapeutic effect of liver transplantation. At present, early clinical studies have reported the unique advantages of ICIs used alone or in combination in downstaging or bridging therapy before liver transplantation for hepatocellular carcinoma and adjuvant therapy after liver transplantation. Therefore, this article reviews the clinical trials of ICIs in liver transplantation for hepatocellular carcinoma and the advances in the application of ICIs in recent years and discuss its safety and efficacy, in order to provide a certain reference for clinical medication.
