Advances in the risk factors, pathogenesis, and treatment of liver cirrhosis with osteoporosis
10.3969/j.issn.1001-5256.2023.04.028
- VernacularTitle:肝硬化合并骨质疏松症的危险因素、发病机制及治疗进展
- Author:
Qiu JIN
1
;
Jing YANG
1
;
Honglin MA
1
;
Qingqing LIU
1
;
Pingju LI
1
;
Shaoshan HU
1
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China
- Publication Type:Review
- Keywords:
Liver Cirrhosis;
Osteoporosis;
Sarcopenia;
Adiponectin;
Irisin
- From:
Journal of Clinical Hepatology
2023;39(4):929-935
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common extrahepatic complication of liver cirrhosis, and it not only increases the economic burden of patients, but also brings adverse effects on their quality of life and prognosis. Recent studies have shown that sarcopenia, adiponectin, leptin, irisin, and inflammatory factors are involved in the development of osteoporosis in patients with liver cirrhosis, and commonly used anti-osteoporosis drugs include calcium supplement, vitamin D, and bisphosphonates. This article reviews the advances in the risk factors, pathogenesis, and treatment of liver cirrhosis with osteoporosis and points out that there are still controversies over the influence of some factors on osteoporosis, and further studies are needed to explore related pathogeneses and safe and effective treatment regimens.
