An investigation of hepatitis D virus infection among patients with chronic hepatitis B virus infection in some regions of China
10.3969/j.issn.1001-5256.2023.04.009
- VernacularTitle:我国部分地区慢性HBV感染者HDV感染情况调查
- Author:
Yumei LIU
1
;
Xiaoping GUO
2
;
Huimin ZHANG
2
;
Hongxia BAI
3
;
Chunmei WANG
4
;
Shan REN
5
;
Yongfang JIANG
6
;
Sheng YANG
6
;
Feng PENG
6
;
Xiaozhong WANG
7
;
Lei YU
8
;
Boming LIAO
9
;
Ling NING
10
;
Yingli HE
11
;
Xia YANG
12
;
Liang HUANG
13
;
Xueen LIU
1
;
Hui ZHUANG
1
Author Information
1. Department of Microbiology and Center of Infectious Diseases, Peking University Health Science Center, Beijing 100191, China
2. Chifeng Infectious Disease Prevention Hospital of Inner Mongolia Autonomous Region, Chifeng, Inner Mongolia Autonomous Region 024099, China
3. Inner Mongolia International Mongolian Medical Hospital, Hohhot 010055, China
4. Hohhot Second Hospital of Inner Mongolia Autonomous Region, Hohhot 010020, China
5. Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
6. Department of Infectious Diseases, The Second Xiangya Hospital of Central South University, Changsha 410011, China
7. Department of Hepatology, Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, China
8. Department of Infectious Diseases, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
9. Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
10. Department of Infectious Diseases, The First Affiliated Hospital of University of Science and Technology of China & Anhui Provincial Hospital, Hefei 230001, China
11. Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
12. Jilin Infectious Disease Hospital, Jilin, Jilin 132002, China
13. Public Health Clinical Center of Chengdu, Chengdu 610066, China
- Publication Type:Original Article_Viral Hepatitis
- Keywords:
Hepatitis B Virus;
Hepatitis Delta Virus;
Anti-HDV IgG;
Genotype
- From:
Journal of Clinical Hepatology
2023;39(4):795-803
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of hepatitis D virus (HDV) infection among patients with chronic hepatitis B virus (HBV) infection in some regions of China. Methods Serum samples were collected from 3 131 patients with chronic HBV infection in 10 provinces, cities, and autonomous regions of China from March 2021 to June 2022, and anti-HDV IgG ELISA was used for the detection of all serum samples. Nested reverse transcription-polymerase chain reaction (nRT-PCR) was used to detect HDV RNA in anti-HDV IgG-positive samples, and the nRT-PCR amplification products of HDV RNA-positive samples were sequenced and analyzed to determine HDV genotype. The clinical features of anti-HDV IgG-positive patients were analyzed. The Mann-Whitney U rank sum test was used for comparison of continuous data between two groups, and the chi-square test or the Fisher's exact test was used for comparison of categorical data between two groups. Results The positive rate of anti-HDV IgG in the 3 131 patients with chronic HBV infection was 0.70% (22/3 131), and that in the patients with chronic HBV infection in Inner Mongolia Autonomous Region, Xinjiang Uygur Autonomous Region, Beijing, and Hunan Province was 1.81% (16/886), 0.88% (2/226), 0.28% (2/708), and 1.00% (2/200), respectively; the patients with chronic HBV infection in Inner Mongolia Autonomous Region had a significantly higher positive rate of anti-HDV IgG than those in Beijing ( P =0.004), and there was no significant difference between the other regions ( P > 0.05). Clinical features of the patients with chronic HBV infection in Inner Mongolia Autonomous Region showed that compared with the anti-HDV IgG-negative group, the anti-HDV IgG-positive group had a significantly higher proportion of patients with Mongol nationality ( P =0.001), abnormal alanine aminotransferase ( P =0.007), or antiviral treatment ( P =0.029), as well as a significantly lower median HBV DNA level ( P =0.030). A total of 19 HDV RNA-positive samples were identified, all of which had HDV genotype 1. Conclusion The prevalence rate of HDV varies greatly across different regions of China, with a higher prevalence rate of HDV in patients with chronic HBV infection from Inner Mongolia Autonomous Region. HDV genotype 1 is the predominant genotype in some provinces and cities of northern China.
