Progress of Transplantation of Neural Stem Cells (review)
- VernacularTitle:神经干细胞移植治疗研究进展
- Author:
Shuyu HAO
;
Hong WAN
;
Zhongcheng WANG
- Publication Type:Journal Article
- Keywords:
neural stem cells, transplantation, mediation, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(8):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Nervous system develops from multipotential stem cells of the embryonic neural tube.The discovery of cells of stem-like properties in the adult central nervous system(CNS)has provoked an intense search for ways to utilize their potential for treatments of multiple neurological disorders.Expansion and recruitment of endogenous progenitors may be limited in treating widespread cell loss in the adult CNS.Transplantation of neural stem cells(NSCs)or more restricted progenitors to replace cells lost to injury or disease may facilitate functional recovery in a spectrum of neurological disorders.A major challenge to the development of effective NSCs therapies is to direct the fate of the newly generated cells to specifically replace those lost to disease.The key to the effective treatment of NSCs is molecular regulation of the differentiation of NSCs and their progeny in areas of injury to the adult CNS,the fate of transplanted stem cells is also important.
