Effects of Transplantation of Bone Marrow Stromal Cells on Expression of Vascular Endothelial Growth Factor after Local Brain Injury in Rats
- VernacularTitle:骨髓基质细胞移植对大鼠局灶性脑损伤VEGF表达的影响
- Author:
Pengfei ZHANG
;
Yazhuo ZHANG
;
Qingguo LI
;
Meizhen SUN
;
Hongyun WANG
;
Le HE
- Publication Type:Journal Article
- Keywords:
bone marrow stromal cells, brain injury, vascular endothelial growth factor(VEGF)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(8):731-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of transplantation of bone marrow stromal cells(BMSCs)on expression of vascular endothelial growth factor(VEGF)after local brain injury in rats.Methods The animal model of local brain injury in rat was established.The human BMSCs(hBMSCs)were transplanted into the local brain.The immunohistochemistry,real-time quantitative PCR,and ELISA were used to observe the changes of VEGF and VEGF mRNA in tissues of local brain.Results After the hBMSCs were transplanted into the animal model,the quantities of the VEGF positive cells increased;real-time quantitative PCR showed that VEGF mRNA of local brain was enhanced.Conclusion The BMSCs transplantation can improve expression of endogenous VEGF and raise the content of VEGF in injured tissues of brain.
