Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis.
10.1016/j.apsb.2022.10.019
- Author:
Mengnan ZHAO
1
;
Rujing WANG
1
;
Kunmeng YANG
2
;
Yuhong JIANG
3
;
Yachen PENG
4
;
Yuke LI
1
;
Zhen ZHANG
1
;
Jianxun DING
4
;
Sanjun SHI
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. The First Norman Bethune College of Clinical Medicine, Jilin University, Changchun 130061, China.
3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
4. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
- Publication Type:Review
- Keywords:
DNA nanotechnology;
DNA origami;
DNA tetrahedron;
Nucleic acid nanoassembly;
RNA detection;
RNA interference;
RNA nanotechnology;
RNA therapy
- From:
Acta Pharmaceutica Sinica B
2023;13(3):916-941
- CountryChina
- Language:English
-
Abstract:
RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging. Recently, more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating. Due to the flexibility and deformability of nucleic acids, the nanoassemblies could be fabricated with different shapes and structures. With hybridization, nucleic acid nanoassemblies, including DNA and RNA nanostructures, can be applied to enhance RNA therapeutics and diagnosis. This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development.
