Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy.

Author: Guan WANG ¹ ; Yongya WU ¹ ; Chengyong WU ¹ ; Wen SHUAI ¹ ; Tingting JIANG ¹ ; Aoxue WANG ¹ ; Faqian BU ¹ ; Qiu SUN ¹ ; Liang OUYANG ¹
Author Information

1. State Key Laboratory of Biotherapy and Cancer Center, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: Cancer therapy; Co-crystal structure; Drug discovery; Selective inhibitor; TRKA
From: Acta Pharmaceutica Sinica B 2023;13(1):440-443
CountryChina
Language:English