Sialic acid-mediated photochemotherapy enhances infiltration of CD8+ T cells from tumor-draining lymph nodes into tumors of immunosenescent mice.
10.1016/j.apsb.2022.06.005
- Author:
Dezhi SUI
1
;
Changzhi LI
1
;
Xueying TANG
1
;
Xianmin MENG
1
;
Junqiang DING
1
;
Qiongfen YANG
1
;
Zhaowei QI
1
;
Xinrong LIU
1
;
Yihui DENG
1
;
Yanzhi SONG
1
Author Information
1. College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
CD8+ T cells;
Doxorubicin;
Immunosenescence;
Indocyanine green;
Liposomes;
Neutrophils;
Photochemotherapy;
Sialic acid
- From:
Acta Pharmaceutica Sinica B
2023;13(1):425-439
- CountryChina
- Language:English
-
Abstract:
Immunoscenescence plays a key role in the initiation and development of tumors. Furthermore, immunoscenescence also impacts drug delivery and cancer therapeutic efficacy. To reduce the impact of immunosenescence on anti-tumor therapy, this experimental plan aimed to use neutrophils with tumor tropism properties to deliver sialic acid (SA)-modified liposomes into the tumor, kill tumor cells via SA-mediated photochemotherapy, enhance infiltration of neutrophils into the tumor, induce immunogenic death of tumor cells with chemotherapy, enhance infiltration of CD8+ T cells into the tumor-draining lymph nodes and tumors of immunosenescent mice, and achieve SA-mediated photochemotherapy. We found that CD8+ T cell and neutrophil levels in 16-month-old mice were significantly lower than those in 2- and 8-month-old mice; 16-month-old mice exhibited immunosenescence. The anti-tumor efficacy of SA-mediated non-photochemotherapy declined in 16-month-old mice, and tumors recurred after scabbing. SA-mediated photochemotherapy enhanced tumor infiltration by CD8+ T cells and neutrophils, induced crusting and regression of tumors in 8-month-old mice, inhibited metastasis and recurrence of tumors and eliminated the immunosenescence-induced decline in antitumor therapeutic efficacy in 16-month-old mice via the light-heat-chemical-immunity conversion.
