Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis.
10.1016/j.apsb.2022.04.002
- Author:
Xiaoyu LIANG
1
;
Huiyang LI
1
;
Xuanling LI
1
;
Xinxin TIAN
1
;
Aiai ZHANG
2
;
Qingzhi LUO
3
;
Jianwei DUAN
1
;
Youlu CHEN
1
;
Liyun PANG
1
;
Chen LI
1
;
Xing-Jie LIANG
4
;
Yong ZENG
5
;
Jing YANG
1
Author Information
1. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China.
2. The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, China.
3. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
4. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
5. Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
H2O2-scavenging;
Highly sensitive;
Nano-bionic system;
Oxidative stress;
Pathological environment;
Precise;
Target
- From:
Acta Pharmaceutica Sinica B
2023;13(1):372-389
- CountryChina
- Language:English
-
Abstract:
In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.
