Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii.
10.1016/S1875-5364(23)60424-8
- Author:
Yalin HU
1
;
Tianqi XU
1
;
Wenjing YIN
2
;
Huaiyu CHENG
1
;
Xia ZHANG
1
;
Ying LIU
1
;
Yubo ZHANG
2
;
Guangxiong ZHOU
3
Author Information
1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 511436, China.
2. Department of Pharmacology, School of Medicine, Guangdong Clinical Translation Center for Targeted Drug, Jinan University, Guangzhou 511436, China.
3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 511436, China. Electronic address: guangxzh@sina.com.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation.;
Sesquiterpene polyester;
Tripterygium wilfordii;
Tripterysine
- MeSH:
Tripterygium/chemistry*;
Esters/pharmacology*;
Interleukin-6;
Lipopolysaccharides/pharmacology*;
Plant Leaves/chemistry*;
Anti-Inflammatory Agents/chemistry*;
Nitric Oxide/analysis*;
Sesquiterpenes/chemistry*;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(3):233-240
- CountryChina
- Language:English
-
Abstract:
The stem and branch extract of Tripterygium wilfordii (Celastraceae) afforded seven new dihydroagarofuran sesquiterpene polyesters [tripterysines A-G (1-7)] and eight known ones (8-15). The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques. The absolute configurations of tripterysines A-C (1-3) and E-G (5-7) were determined by X-ray crystallographic analysis and circular dichroism spectra. All the compounds were screened for their inhibitory effect on inflammation through determining their inhibitory effect on nitric oxide production in LPS-induced RAW 264.7 cells and the secretion of inflammatory cytokines TNF-α and IL-6 in LPS-induced BV2 macrophages. Compound 9 exhibited significant inhibitory activity on NO production with an IC50 value of 8.77 μmol·L-1. Moreover, compound 7 showed the strongest inhibitory effect with the secretion of IL-6 at 27.36%.
