Five new spirosterol saponins from Allii Macrostemonis Bulbus.
10.1016/S1875-5364(23)60423-6
- Author:
Rong WANG
1
;
Lulu WANG
2
;
Manli ZHANG
3
;
Yadi GUO
1
;
Jing ZHANG
4
;
Guoxu MA
5
Author Information
1. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
2. College of Medicine, Changchun University of Science and Technology, Changchun 130600, China.
3. Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
4. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. Electronic address: zhjing0701@163.com.
5. Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address: mgxflfl8785@163.com.
- Publication Type:Journal Article
- Keywords:
Allii Macrostemonis Bulbus;
Antioxidant;
Spirosterol saponin
- MeSH:
Saponins/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Magnetic Resonance Spectroscopy;
Antioxidants/pharmacology*;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(3):226-232
- CountryChina
- Language:English
-
Abstract:
Five new spirostanol saponins (1-5) and seven known compounds (6-12) were isolated from the n-butanol fraction of 75% ethanol extract of Allii Macrostemonis Bulbus. The identification and structural elucidation of all the isolates were performed through extensive 1D and 2D NMR experiments, HR-ESI-MS data analysis and comparisons with literature values. Antioxidant evaluation showed that compounds 6-11 exhibited certain scavenging effects on ABTS radical, where compounds 6, 7 and 11 had IC50 values of 0.208, 0.057 and 0.014 mg·mL-1, respectively.
