Antimicrobial indole alkaloids from Tabernaemontana corymbosa.
10.1016/S1875-5364(23)60393-0
- Author:
Kun FAN
1
;
Lanchun ZHANG
1
;
Bangyin TAN
1
;
Guy S S NJATENG
2
;
Malong QIN
1
;
Ruirong GUO
1
;
Xiaojuan HUANG
1
;
Cai-Feng DING
1
;
Weimin GAO
3
;
Rongping ZHANG
4
;
Haofei YU
5
Author Information
1. School of Pharmaceutical Sciences, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
2. Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
3. School of Pharmaceutical Sciences, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China. Electronic address: gaoweimin@kmmu.edu.cn.
4. School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Resources, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China. Electronic address: zhrpkm@163.com.
5. School of Pharmaceutical Sciences, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China. Electronic address: yuhaofei@kmmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antimicrobial activity;
Indole alkaloid;
Tabernaemontana corymbosa
- MeSH:
Tabernaemontana;
Anti-Infective Agents;
Antifungal Agents;
Anti-Bacterial Agents;
Indole Alkaloids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(2):146-153
- CountryChina
- Language:English
-
Abstract:
Four unreported monoterpene indole alkaloids, tabernaecorymines B-E (1-4), together with twenty-one known indole alkaloids (5-25) were obtained from the stem bark of Tabernaemontana corymbosa. Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, DP4+ probability analyses and Mo2(OAc)4-induced electronic circular dichroism experiment. The antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis, Streptococcus dysgalactiae and Candida albicans.
