Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.
10.1016/S1875-5364(23)60385-1
- Author:
Khan SALMAN
1
;
Hongjie ZHU
1
;
Ziqian SUN
1
;
Yilin LI
2
,
3
;
Lan WANG
1
;
Rong WANG
4
;
Zhikai GUO
5
,
6
;
Ruihua JIAO
7
Author Information
1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093, China.
2. Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Haikou 571101, China
3. Hainan Academy of Ocean and Fisheries Sciences, Hainan Tropical Ocean University, Haikou 571126, China.
4. Hainan Academy of Ocean and Fisheries Sciences, Hainan Tropical Ocean University, Haikou 571126, China.
5. Hainan Key Laboratory of Tropical Microbe Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
6. Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Haikou 571101, China. Electronic address: guozhikai@itbb.org.cn.
7. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address: rhjiao@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antibacterial;
Aspergillus sp.;
Cytotoxic;
Drimane-type;
Fungus;
Sesquiterpenoids
- MeSH:
Humans;
Polycyclic Sesquiterpenes;
Sesquiterpenes/chemistry*;
Aspergillus/chemistry*;
Magnetic Resonance Spectroscopy;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(1):58-64
- CountryChina
- Language:English
-
Abstract:
Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived Aspergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one- and two-dimensional NMR spectroscopy. Drimanenoids A-F (1-6) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. Drimanenoids C (3), D (4) and F (6) showed antibacterial activity against five types of bacteria with different inhibition diameters. Drimanenoid D (4) exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88 ± 0.11 μmol·L-1.
