Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway.
10.1016/S1875-5364(23)60383-8
- Author:
Mengru WANG
1
;
Baopeng TIAN
1
;
Jie SHEN
1
;
Shilin XU
1
;
Cong LIU
1
;
Ling GUAN
1
;
Min GUO
2
;
Jie DOU
3
Author Information
1. College of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China.
2. College of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. Electronic address: 1020152471@cpu.edu.cn.
3. College of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. Electronic address: doujie@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Bavachin;
Colorectal cancer;
Gadd45a;
MAPK
- MeSH:
Humans;
Signal Transduction;
Flavonoids/pharmacology*;
Proteins/pharmacology*;
MAP Kinase Signaling System;
Colorectal Neoplasms/metabolism*;
Apoptosis;
Cell Line, Tumor;
Cell Proliferation;
Cell Cycle Proteins/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(1):36-46
- CountryChina
- Language:English
-
Abstract:
Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia, and exhibits anti-bacterial, anti-inflammatory, anti-tumor and lipid-lowering activities. Recent attention has gradually drawn on bavachin-induced apoptosis in many human cancer cell lines. However, the anti-cancer effects and related mechanisms in colorectal cancer remain unknown. Here, we investigated the effects of bavachin on colorectal cancer in vivo and in vitro. The results showed that bavachin inhibited the proliferation of human colorectal cancer cells and induce apoptosis. These changes were mediated by activating the MAPK signaling pathway, which significantly up-regulated the expression of Gadd45a. Furthermore, Gadd45a silencing obviously attenuated bavachin-mediated cell apoptosis. Inhibition of the MAPK signaling pathway by JNK/ERK/p38 inhibitors also weakened the up-regulation of Gadd45a by bavachin. The anticancer effect of bavachin was also validated using a mouse xenograft model of human colorectal cancer. In conclusion, these findings suggest that bavachin induces the apoptosis of colorectal cancer cells through activating the MAPK signaling pathway.
