Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools.
10.1016/S1875-5364(23)60382-6
- Author:
Kamau PETER MUIRURI
1
,
2
;
Jian ZHONG
3
,
4
,
5
;
Bing YAO
3
,
4
,
5
;
Ren LAI
1
,
6
,
7
;
Lei LUO
8
Author Information
1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, China
2. Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
3. Department of Reproductive Medicine, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing 210002, China
4. Department of Gynecology, Womenapos
5. s Hospital of Nanjing Medical University, Nanjing 210004, China.
6. Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
7. Center for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China. Electronic address: rlai@mail.kiz.ac.cn.
8. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, China. Electronic address: luolei@mail.kiz.ac.cn.
- Publication Type:Review
- Keywords:
Drug development;
Pharmacological properties;
Scorpion venom-derived peptides;
Scorpion venoms
- MeSH:
Animals;
Scorpion Venoms/pharmacology*;
Peptides/pharmacology*;
Scorpions;
Drug Development;
Medicine, Traditional
- From:
Chinese Journal of Natural Medicines (English Ed.)
2023;21(1):19-35
- CountryChina
- Language:English
-
Abstract:
Evolution and natural selection have endowed animal venoms, including scorpion venoms, with a wide range of pharmacological properties. Consequently, scorpions, their venoms, and/or their body parts have been used since time immemorial in traditional medicines, especially in Africa and Asia. With respect to their pharmacological potential, bioactive peptides from scorpion venoms have become an important source of scientific research. With the rapid increase in the characterization of various components from scorpion venoms, a large number of peptides are identified with an aim of combating a myriad of emerging global health problems. Moreover, some scorpion venom-derived peptides have been established as potential scaffolds helpful for drug development. In this review, we summarize the promising scorpion venoms-derived peptides as drug candidates. Accordingly, we highlight the data and knowledge needed for continuous characterization and development of additional natural peptides from scorpion venoms, as potential drugs that can treat related diseases.
