Therapeutic potential of rutin in male infertility: A mini review.
10.1016/j.joim.2023.01.004
- Author:
Damilare Emmanuel ROTIMI
1
,
2
;
Tobiloba Christiana ELEBIYO
1
,
2
;
Oluwafemi Adeleke OJO
3
Author Information
1. SDG 03 Group-Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria
2. Department of Biochemistry, Landmark University, Omu-Aran 251101, Kwara State, Nigeria.
3. Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo 232101, Osun State, Nigeria. Electronic address: oluwafemiadeleke08@gmail.com.
- Publication Type:Review
- Keywords:
Antioxidant;
Inflammation;
Rutin;
Sperm;
Testicular function
- MeSH:
Male;
Humans;
Rutin/analysis*;
Semen;
Testis;
Spermatozoa;
Oxidative Stress;
Infertility, Male/drug therapy*
- From:
Journal of Integrative Medicine
2023;21(2):130-135
- CountryChina
- Language:English
-
Abstract:
Male infertility has become a problem worldwide, and recent research has emphasized the development of more effective therapy options. Among natural compounds, rutin has been widely studied for its potential to treat dysfunction related to male infertility, including a reduction in sperm quality, spermatogenesis disruption and structural disruption in the testis. A thorough review of scientific literature published in several databases, including Google Scholar, PubMed/MEDLINE and Scopus, was used to synthesize the present state of research on the role of rutin in male reproductive health. Rutin has been shown to possess antiapoptotic, antioxidant and anti-inflammatory activities, among others, which are crucial in the management of male infertility. Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved. The present review, therefore, assesses the therapeutic mechanisms involved in male infertility treatment using rutin. Rutin was able to mitigate the induced oxidative stress, apoptosis, inflammation, and related physiological processes that can cause testicular dysfunction. Please cite this article as: Rotimi DE, Elebiyo TC, Ojo OA. Therapeutic potential of rutin in male infertility: A mini review. J Integr Med. 2023; 21(2): 130-135.
