J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China.

Panpan HE; Huan LI; Mengyi Liu; Zhuxian Zhang; Yuanyuan Zhang; Chun Zhou; Ziliang YE; Qimeng WU; Min Liang; Jianping Jiang; Guobao Wang; Jing Nie; Fan Fan Hou; Chengzhang Liu; Xianhui Qin

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J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China.

Author: Panpan HE ^{1
,

2
,

3
,

4} ; Huan LI ^{1
,

2
,

3
,

4} ; Mengyi LIU ^{1
,

2
,

3
,

4} ; Zhuxian ZHANG ^{1
,

2
,

3
,

4} ; Yuanyuan ZHANG ^{1
,

2
,

3
,

4} ; Chun ZHOU ^{1
,

2
,

3
,

4} ; Ziliang YE ^{1
,

2
,

3
,

4} ; Qimeng WU ^{1
,

2
,

3
,

4} ; Min LIANG ^{1
,

2
,

3
,

4} ; Jianping JIANG ^{1
,

2
,

3
,

4} ; Guobao WANG ^{1
,

2
,

3
,

4} ; Jing NIE ^{1
,

2
,

3
,

4} ; Fan Fan HOU ^{1
,

2
,

3
,

4} ; Chengzhang LIU ⁵ ; Xianhui QIN ^{1
,

2
,

3
,

6}
Author Information

1. Division of Nephrology, Nanfang Hospital, Southern Medical University
2. National Clinical Research Center for Kidney Disease
3. State Key Laboratory of Organ Failure Research
4. Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
5. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, China.
6. Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China. pharmaqin@126.com.
Publication Type:Journal Article
Keywords: CHNS; dietary zinc intake; general population; new-onset hypertension
MeSH: Adult; Humans; Cohort Studies; Zinc; Diet; Hypertension/epidemiology*; Eating; China/epidemiology*
From: Frontiers of Medicine 2023;17(1):156-164
CountryChina
Language:English
Abstract: We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure ≽ 140 mmHg or diastolic blood pressure ≽ 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88-0.98) in participants with zinc intake < 10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11-1.16) in participants with zinc intake ≽ 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.