Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques.

Dali Tong; Mei Zhang; Yunru Yang; Han Xia; Haiyang Tong; Huajun Zhang; Weihong Zeng; Muziying Liu; Yan WU; Huan MA; Xue HU; Weiyong Liu; Yuan Cai; Yanfeng Yao; Yichuan Yao; Kunpeng Liu; Shifang Shan; Yajuan LI; Ge Gao; Weiwei Guo; Yun Peng; Shaohong Chen; Juhong Rao; Jiaxuan Zhao; Juan Min; Qingjun Zhu; Yanmin Zheng; Lianxin Liu; Chao Shan; Kai Zhong; Zilong Qiu; Tengchuan Jin; Sandra Chiu; Zhiming Yuan; Tian Xue

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Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques.

Author: Dali TONG ¹ ; Mei ZHANG ¹ ; Yunru YANG ¹ ; Han XIA ² ; Haiyang TONG ³ ; Huajun ZHANG ⁴ ; Weihong ZENG ⁵ ; Muziying LIU ⁶ ; Yan WU ⁴ ; Huan MA ⁵ ; Xue HU ² ; Weiyong LIU ¹ ; Yuan CAI ¹ ; Yanfeng YAO ⁴ ; Yichuan YAO ¹ ; Kunpeng LIU ² ; Shifang SHAN ⁷ ; Yajuan LI ⁸ ; Ge GAO ⁴ ; Weiwei GUO ² ; Yun PENG ⁴ ; Shaohong CHEN ² ; Juhong RAO ² ; Jiaxuan ZHAO ² ; Juan MIN ⁴ ; Qingjun ZHU ³ ; Yanmin ZHENG ³ ; Lianxin LIU ¹ ; Chao SHAN ² ; Kai ZHONG ³ ; Zilong QIU ⁷ ; Tengchuan JIN ¹ ; Sandra CHIU ¹ ; Zhiming YUAN ⁴ ; Tian XUE ¹
Author Information

1. First Affiliated Hospital of USTC, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
3. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
4. Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
5. Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, CAS Key Laboratory of Innate Immunity and Chronic Disease, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230026, China.
6. Anhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei 230051, China.
7. Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
8. Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Publication Type:Journal Article
MeSH: Animals; SARS-CoV-2; Antibodies, Neutralizing; Macaca mulatta; COVID-19/prevention & control*; Antibodies, Viral; Vaccines
From: Protein & Cell 2023;14(1):69-73
CountryChina
Language:English