Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders.
10.1007/s12264-022-01013-6
- Author:
Lijuan ZHANG
1
;
Yafei WANG
1
;
Taohui LIU
1
;
Ying MAO
1
;
Bo PENG
2
Author Information
1. Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200040, China.
2. Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200040, China. peng@fudan.edu.cn.
- Publication Type:Review
- Keywords:
Microglia;
Microglial replacement;
Multifunction;
Neurodegeneration;
Neuroinflammation
- MeSH:
Humans;
Microglia/physiology*;
Central Nervous System;
Neurodegenerative Diseases/therapy*;
Brain/physiology*;
Homeostasis
- From:
Neuroscience Bulletin
2023;39(3):491-502
- CountryChina
- Language:English
-
Abstract:
As prominent immune cells in the central nervous system, microglia constantly monitor the environment and provide neuronal protection, which are important functions for maintaining brain homeostasis. In the diseased brain, microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular responses. In this review, we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration. We further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases. Notably, we propose microglial depletion and subsequent repopulation as promising replacement therapy. Although microglial replacement therapy is still in its infancy, it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.
