Neural Correlates of Spatial Navigation in Primate Hippocampus.
10.1007/s12264-022-00968-w
- Author:
Dun MAO
1
Author Information
1. Center for Excellence in Brain Science and Intelligent Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China. dunmao@ion.ac.cn.
- Publication Type:Review
- Keywords:
Eye and head coordinates;
Hippocampus;
Mixed selectivity;
Primate;
Spatial navigation;
Task dependency;
Theta activity
- MeSH:
Animals;
Humans;
Spatial Navigation/physiology*;
Hippocampus/physiology*;
Primates;
Neurons/physiology*;
Theta Rhythm/physiology*
- From:
Neuroscience Bulletin
2023;39(2):315-327
- CountryChina
- Language:English
-
Abstract:
The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks.
