Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease.

Author: Ying BAI ¹ ; Hui REN ¹ ; Liang BIAN ¹ ; You ZHOU ¹ ; Xinping WANG ¹ ; Zhongli XIONG ¹ ; Ziqi LIU ¹ ; Bing HAN ¹ ; Honghong YAO ²
Author Information

1. Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing, 210009, China.
2. Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing, 210009, China. yaohh@seu.edu.cn.
Publication Type:Review
Keywords: Astrocytes; Circular RNA; Long noncoding RNA; MicroRNA; Microglia; Noncoding RNA; Oligodendrocytes
MeSH: Humans; RNA, Untranslated/genetics*; MicroRNAs/genetics*; RNA, Long Noncoding/genetics*; RNA, Circular; Central Nervous System Diseases/genetics*
From: Neuroscience Bulletin 2023;39(3):440-452
CountryChina
Language:English
Abstract: Non-coding RNAs (ncRNAs) are a class of functional RNAs that play critical roles in different diseases. NcRNAs include microRNAs, long ncRNAs, and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes of central nervous system (CNS) diseases. Mounting evidence indicates that ncRNAs play key roles in CNS diseases. Further elucidating the mechanisms of ncRNA underlying the process of regulating glial function that may lead to the identification of novel therapeutic targets for CNS diseases.