Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice.
10.1007/s12264-022-00889-8
- Author:
Xiaoke XIE
1
;
Shangyue GONG
2
;
Ning SUN
3
;
Jiazhu ZHU
4
;
Xiaobin XU
3
;
Yongxian XU
3
;
Xiaojing LI
3
;
Zhenhong DU
4
;
Xuanting LIU
3
;
Jianmin ZHANG
2
;
Wei GONG
5
;
Ke SI
6
Author Information
1. Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310012, China.
2. Department of Neurosurgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310012, China.
3. MOE Frontier Science Center for Brain Science & Brain-Machine Integration, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310012, China.
4. Intelligent Optics & Photonics Research Center, Jiaxing Research Institute, Zhejiang University, Jiaxing, 314001, China.
5. Department of Neurosurgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310012, China. weigong@zju.edu.cn.
6. Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310012, China. kesi@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Calcium imaging;
Contextual fear conditioning;
Cortical plasticity;
Learning and memory;
Microglial depletion;
Primary visual cortex
- MeSH:
Mice;
Animals;
Primary Visual Cortex;
Extinction, Psychological/physiology*;
Learning/physiology*;
Fear/physiology*;
Hippocampus/physiology*
- From:
Neuroscience Bulletin
2023;39(1):29-40
- CountryChina
- Language:English
-
Abstract:
Fear memory contextualization is critical for selecting adaptive behavior to survive. Contextual fear conditioning (CFC) is a classical model for elucidating related underlying neuronal circuits. The primary visual cortex (V1) is the primary cortical region for contextual visual inputs, but its role in CFC is poorly understood. Here, our experiments demonstrated that bilateral inactivation of V1 in mice impaired CFC retrieval, and both CFC learning and extinction increased the turnover rate of axonal boutons in V1. The frequency of neuronal Ca2+ activity decreased after CFC learning, while CFC extinction reversed the decrease and raised it to the naïve level. Contrary to control mice, the frequency of neuronal Ca2+ activity increased after CFC learning in microglia-depleted mice and was maintained after CFC extinction, indicating that microglial depletion alters CFC learning and the frequency response pattern of extinction-induced Ca2+ activity. These findings reveal a critical role of microglia in neocortical information processing in V1, and suggest potential approaches for cellular-based manipulation of acquired fear memory.
