Depressive symptoms are not associated with risks of rapid renal function decline or chronic kidney disease in middle-aged and elderly with normal kidney function: a longitudinal investigation.
10.12122/j.issn.1673-4254.2023.02.10
- Author:
Meng Di YANG
1
;
Hong Tao YIN
1
;
Jie Yu ZHEN
2
;
Yu Lu DING
1
;
Yu Jie WANG
1
;
Lin Nan SUN
1
;
Feng Ying HE
1
;
Dong Hu ZHEN
3
Author Information
1. First Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
2. Department of Gynecology, Gansu Provincial People's Hospital, Lanzhou 730000, China.
3. Department of Endocrinology, First Hospital of Lanzhou University, Lanzhou 730030, China.
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
depressive symptoms;
kidney function decline
- MeSH:
Aged;
Middle Aged;
Humans;
Cohort Studies;
Depression;
Glomerular Filtration Rate;
Disease Progression;
Renal Insufficiency, Chronic/epidemiology*;
Kidney/physiology*;
Risk Factors
- From:
Journal of Southern Medical University
2023;43(2):225-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association between depressive symptoms and the risks of rapid decline in renal function and chronic kidney disease (CKD) in middle-aged and elderly with normal kidney function.
METHODS:The residents aged 40- 75 years with eGFR≥60 mL·min-1·1.73 m-2 without proteinuria in Lanzhou region, who participated in the "REACTION" study carried out in 2011, were selected and followed up in 2014. A total of 4961 individuals with complete and qualified data from the two surveys were included in the subsequent analysis. Based on PHQ-9 questionnaire scores, the baseline population was divided into two groups with and without depressive symptoms. Cox proportional hazard analysis was used to compare the incidences of rapid renal function decline and CKD between the two groups and study the association of depressive symptoms with the risk of these renal conditions.
RESULTS:PHQ-9 questionnaire scores were not found to correlate with baseline SCr, ALB, UACR or eGFR levels among the participarts (P>0.05). After a mean follow-up time of 3.4±0.6 years, 33.9% of the participants with depressive symptoms at baseline experienced a rapid decline in renal function and 3.6% progressed to CKD. During the follow-up, the incidence of rapid decline in renal function and the risk of developing CKD were not found to correlate with depressive symptoms in these participants (P>0.05) regardless of the type of the depressive syndromes.
CONCLUSION:Depressive symptoms are not associated with the risks of rapid renal function decline or progression to CKD in middle-aged and elderly with normal kidney function.
