A multi-center analysis of thyroid-stimulating hormone level in apparently healthy elderly population in China.
10.12122/j.issn.1673-4254.2023.01.01
- Author:
Ke Yu WANG
1
;
Hai Xia LI
2
;
Xin Li DENG
1
;
Shuang Tong YAN
3
;
Yu Rong QIU
2
;
Yu Long CONG
1
Author Information
1. Department of Clinical Laboratory, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
3. Department of Endocrinology, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- Keywords:
elderly population;
gender;
reference range;
thyroid-stimulating hormone
- MeSH:
Aged;
Female;
Humans;
Male;
Middle Aged;
Asian People;
China;
Fasting;
Health Status;
Thyrotropin/blood*
- From:
Journal of Southern Medical University
2023;43(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate serum thyroid stimulating hormone (TSH) level and its changes with age in apparently healthy Chinese elderly population and analyze the differences between TSH levels detected using Roche and Snibe electrochemiluminescence immunoassay analyzers.
METHODS:General clinical data and frozen fasting serum samples were collected from 5451 apparently healthy Chinese elderly individuals (> 60 years) from 10 centers in different geographic regions in China. Thyroid function indexes including TSH level were detected using Roche and Snibe electrochemiluminescence immunoassay analyzer, and the median (2.5% and 97.5% quantiles) TSH level was calculated. The variations of TSH level among the participants with geographic regions, gender, and age (with an interval of 5 years) were analyzed to determine the influence of these factors on TSH level.
RESULTS:The reference ranges of serum TSH level established using Roche and Snibe electrochemiluminescence immunoassay analyzers were 0.42-9.47 mU/L and 0.36-7.98 mU/L, respectively, showing significant differences between the two methods (P < 0.001). The TSH levels measured at two centers in Western China were significantly higher than those at the other centers (P < 0.05). In elderly male population, serum TSH level tended to increase with age, which was not observed in elderly female population. At the age of 60-75 years, women generally had higher serum TSH level than men, but this difference was not observed in the population beyond 75 years.
CONCLUSION:In elderly population, serum TSH level can vary with geographic region, gender, and age, but there was no need for establishing specific reference ranges for these factors. The differences between different detection methods should be evaluated when interpreting the detection results of TSH level.
