Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model.

Hanyu Wang; Yuanhao Yang; Xiao Zhang; Yan Wang; Hui Fan; Jinfeng Shi; Xuelian Tan; Baoshi XU; Jingchao Qiang; Enzhuang Pan; Mingyi Chu; Zibo Dong; Jingquan Dong

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Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model.

Author: Hanyu WANG ¹ ; Yuanhao YANG ² ; Xiao ZHANG ¹ ; Yan WANG ² ; Hui FAN ¹ ; Jinfeng SHI ¹ ; Xuelian TAN ¹ ; Baoshi XU ¹ ; Jingchao QIANG ¹ ; Enzhuang PAN ¹ ; Mingyi CHU ¹ ; Zibo DONG ³ ; Jingquan DONG ⁴
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1. Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
2. Department of Rheumatology and Immunology, the Second People's Hospital of Lianyungang City, Lianyungang 222000, China.
3. Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China. dongzibo999@163.com.
4. Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China. dongzibo999@163.com, 2018000029@jou.edu.cn.
Publication Type:Journal Article
MeSH: Mice; Animals; Lipopolysaccharides/pharmacology*; Spleen; Inflammation; Apoptosis; Sepsis; Oxidative Stress
From: Journal of Zhejiang University. Science. B 2023;24(2):185-190
CountryChina
Language:English
Abstract: Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. Liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.